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Worsening headache with vomiting and drowsiness, a first seizure, or sudden weakness needs emergency assessment today. These may indicate rising pressure inside the skull or bleeding. Go to your nearest hospital — do not arrange travel first.

Home  /  Treatments  /  Neurosurgery  /  Brain tumours and gliomas

Brain tumours: surgery and what determines the outcome

Tumours arising within the brain itself, or spreading to it from elsewhere. What can be done depends far less on the name of the tumour than on precisely where it sits.

Two patients with the same diagnosis can face completely different operations, because a tumour two centimetres from the speech area is a different problem from the same tumour in a silent region. This is why we ask for the images rather than the report.

Decides everything
Tumour location
Not the diagnosis label
Aim of surgery
Maximal safe removal
How much correlates with outcome in most tumours
Awake surgery
Where speech is at risk
Function is tested during the operation
Time in India
3 to 5 weeks
Including histology and post-operative scan
The condition

What brain tumours are

Tumours arising from brain tissue itself are called gliomas, and they range from slow-growing low-grade tumours that may be watched for years to glioblastoma, which is aggressive and treated urgently. Meningiomas arise from the covering membranes rather than the brain, are usually benign, and have their own page. Pituitary tumours and acoustic neuromas likewise.

Secondary tumours — deposits that have spread from a cancer elsewhere, most often lung, breast or kidney — are more common than primary brain tumours. Their treatment depends on the original cancer as much as on the deposit itself, and radiosurgery frequently plays a larger role than open surgery.

What matters most in every case is location. The brain has areas where a tumour can be removed generously with no functional cost, and areas where a millimetre in the wrong direction leaves permanent weakness or loss of speech. The MRI is what shows which situation applies, and a surgeon needs to see the images rather than read a description of them.

For most tumour types, how much is removed correlates with how long the patient lives and how long before it returns. The surgeon's task is to remove as much as possible without causing a deficit — and how well they balance those two things is what separates good neurosurgery from adequate neurosurgery.

Symptoms

Symptoms and warning signs

Common symptoms
  • Headache, characteristically worse in the morning or on lying flat
  • Nausea and vomiting, often without nausea beforehand
  • Seizures, including a first seizure in an adult
  • Progressive weakness or numbness on one side
  • Difficulty finding words or understanding speech
  • Visual disturbance or double vision
  • Personality change, confusion or unusual drowsiness noticed by family
Warning signs of an emergency
  • Rapidly worsening headache with vomiting
  • Increasing drowsiness or difficulty waking
  • A first seizure, or seizures becoming more frequent
  • Sudden weakness, numbness or speech difficulty
  • New double vision or loss of vision
  • Confusion or unusual behaviour developing over days

Rising pressure inside the skull is an emergency, not a symptom to research

Headache that is worse on waking or lying flat, accompanied by vomiting, drowsiness or double vision, suggests pressure building inside the skull. This needs assessment at your nearest hospital today, and treatment with steroids or drainage may be required before any surgery can be planned. It is also a situation in which air travel is unsafe. Tell us immediately if this describes you, and see a doctor locally without waiting for our reply.

Diagnosis

How it is diagnosed

Imaging establishes the picture; tissue establishes the diagnosis.

Initial tests

  • MRI of the brain with contrast — the essential test, showing the tumour, its relationship to critical structures and its likely nature
  • CT scan — quicker and often the first test in an emergency, but far less informative than MRI
  • Blood tests — routine pre-operative assessment
  • Examination of vision and neurological function — baseline before treatment

The deciding tests

  • Functional MRI and tractography — maps speech, movement and the fibre tracts connecting them, guiding how much can be removed safely
  • MR spectroscopy or perfusion — helps distinguish tumour types and separate tumour from treatment change
  • CT chest, abdomen and pelvis — where a secondary tumour is suspected, to find the primary cancer
  • Biopsy or surgical specimen — with molecular testing, which now determines treatment and prognosis as much as the microscope does

Molecular testing has changed how these tumours are classified

Gliomas are now classified by genetic markers — IDH mutation, 1p/19q co-deletion, MGMT methylation — as much as by appearance under the microscope. These determine treatment and outlook, and two tumours that look identical can behave completely differently depending on them. If you have a histology report without molecular results, ask whether testing can be done on the stored tissue.

Options

Treatment options

Surgery is usually first, but not always, and not for everyone.

Option one

Surveillance

Small, low-grade tumours causing no symptoms are sometimes best monitored with periodic MRI rather than operated on, particularly where the location makes surgery risky. Watching is an active decision requiring a clear plan of scan intervals, not simply doing nothing.

Usually appropriate whenA small, low-grade or incidental tumour in a risky location, causing no symptoms and not growing.
Option two

Maximal safe resection

Removing as much tumour as possible without causing a deficit. Navigation guides the surgeon to the target, neurophysiological monitoring warns when critical pathways are approached, and intraoperative ultrasound or MRI shows what remains. For most tumour types, the extent of removal correlates directly with outcome.

Usually appropriate whenMost accessible tumours causing symptoms or growing, where removal is achievable without unacceptable functional cost.
Option three

Awake craniotomy

Where the tumour lies close to speech or motor areas, part of the operation is performed with you awake, talking or moving while the surgeon works. The brain itself feels no pain. It allows more tumour to be removed safely because function is tested directly rather than predicted, and it is well tolerated by most patients.

Usually appropriate whenTumours adjacent to areas controlling speech or movement.
Option four

Radiotherapy, radiosurgery and chemotherapy

Radiotherapy follows surgery for most malignant tumours and treats those that cannot be operated on. Stereotactic radiosurgery delivers a focused dose in one or a few sessions and is particularly useful for small secondary deposits. Chemotherapy, and increasingly targeted drugs chosen on molecular results, follow for specific tumour types.

Usually appropriate whenAfter surgery for malignant tumours, or as primary treatment where surgery is not appropriate.
The decision

How the choice is made

Location, from the images

This determines what is achievable and at what functional cost. It cannot be assessed from a report — the surgeon needs the images.

Tumour type and molecular profile

A low-grade IDH-mutant glioma and a glioblastoma call for entirely different urgency and treatment, even where they look similar on a scan.

Your neurological condition and general health

A patient already significantly disabled by the tumour may gain little from a large operation. This deserves an honest conversation before, not after.

We will tell you if we believe surgery would cost you more function than it would buy in time. That is the hardest opinion to give and the one most worth having.

Urgency

How urgent is your case

Usually safe to plan travel
  • Stable symptoms, alert and well
  • Imaging complete, planning surgery
  • Seizures controlled on medication
  • Seeking a second opinion on a proposed plan
Needs local assessment before travel
  • Worsening headache with vomiting or drowsiness
  • A first seizure not yet investigated
  • Rapidly progressive weakness or speech loss
  • New visual loss
  • Confusion or reduced consciousness

We will tell you which column you are in

Rising intracranial pressure and uncontrolled seizures both make flying unsafe and both need local treatment first. Once stabilised, travelling for surgery becomes reasonable.

Next step

What to send us

Photographs taken on your phone are fine. Reports in Arabic, Russian or Bengali are fine — we translate them ourselves.

Most useful

  • MRI images on disc or as DICOM files, plus the report
  • Any previous scans for comparison
  • Histology report with molecular results if a biopsy has been done
  • A description of symptoms and how quickly they developed

Also helpful

  • CT scans if performed
  • List of current medication including steroids and anti-seizure drugs
  • CT of chest, abdomen and pelvis if a secondary tumour is suspected
  • Your age and other medical conditions
Questions

Questions patients ask

That depends almost entirely on where it sits. In an accessible location, complete removal may be achievable. Adjacent to speech or motor areas, the surgeon removes as much as can be taken without causing a deficit — which is why awake surgery and monitoring exist. A surgeon who has seen your images can answer this; a report cannot.

Most patients find it far less distressing than they expect. The brain has no pain sensation, the scalp is anaesthetised, and you are sedated for the opening and closing. During the awake portion you talk to a speech therapist or move your hand while the surgeon works. It exists to protect your function, and patients who have had it generally say the anticipation was worse than the experience.

Gliomas are now classified by genetic features as much as by appearance. IDH mutation generally indicates a better outlook. MGMT methylation predicts better response to a particular chemotherapy. 1p/19q co-deletion identifies a tumour type that responds especially well to combined treatment. If your histology report lacks these, ask whether testing can be done on the stored tissue — it may change your treatment.

It depends on the tumour, the surgery and whether you have had seizures. Driving restrictions after a seizure or brain surgery vary by country and are usually measured in months. Cognitive recovery continues for a long time after the wound has healed. Ask specifically about both before surgery so you can plan.

Sometimes, and it depends on how well the original cancer is controlled, how many deposits there are, and whether one is causing pressure symptoms. A single accessible deposit with the primary cancer controlled is often worth removing. Multiple small deposits are more usually treated with radiosurgery. Send both the brain imaging and the staging scans.

In brain tumour surgery, frequently yes — particularly on whether an operation is needed at all and on how much can safely be removed. Opinions differ legitimately between surgeons, and the difference matters. Send the MRI images and we will have them reviewed at no cost, including when the answer is that surveillance is better than surgery.

Contact

Send us your reports

Send the MRI images if you can obtain them on a disc or as files. For brain tumours the images tell a surgeon what no report can.

Your reports go directly to our medical team. We do not share your records with hospitals until you tell us to.

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